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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C121778
http://purl.obolibrary.org/obo/NCIT_C121778
|
|---|---|
| Preferred Name | Sotevtamab |
| Definitions |
A humanized, immunoglobulin (Ig) G2 monoclonal antibody against the secreted form of human clusterin (sCLU) expressed by tumor cells, with potential antineoplastic and anti-metastatic activities. Upon administration, sotevtamab specifically binds to tumor-associated sCLU and inhibits its activity. This inhibits both the sCLU-mediated signal transduction pathways and epithelial-to-mesenchymal transition (EMT), which leads to the inhibition of tumor cell migration and invasion. In addition, sotevtamab enhances chemo-sensitivity. sCLU, a heterodimeric disulfide-linked glycoprotein overexpressed by various types of cancer cells, contributes to proliferation and survival of cancer cells, and stimulates tumor cell EMT.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A humanized, immunoglobulin (Ig) G2 monoclonal antibody against the secreted form of human clusterin (sCLU) expressed by tumor cells, with potential antineoplastic and anti-metastatic activities. Upon administration, sotevtamab specifically binds to tumor-associated sCLU and inhibits its activity. This inhibits both the sCLU-mediated signal transduction pathways and epithelial-to-mesenchymal transition (EMT), which leads to the inhibition of tumor cell migration and invasion. In addition, sotevtamab enhances chemo-sensitivity. sCLU, a heterodimeric disulfide-linked glycoprotein overexpressed by various types of cancer cells, contributes to proliferation and survival of cancer cells, and stimulates tumor cell EMT. |
|---|---|
| prefLabel | Sotevtamab
|
| label | Sotevtamab
|
| PDQ_Closed_Trial_Search_ID | 771181
|
| code | C121778
|
| prefixIRI | NCIT:C121778
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| in_subset |
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| Display_Name | Sotevtamab
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| Preferred_Name | Sotevtamab
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| FDA_UNII_Code | YQ3YJK67AF
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Anti-sCLU Monoclonal Antibody AB-16B5
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| CAS_Registry | 2411526-47-9
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| NCI_Drug_Dictionary_ID | 771181
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 771181
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Immunologic Factor
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| UMLS_CUI | C4053577
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