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Biological and Environmental Research Ontology
| Id | http://purl.obolibrary.org/obo/NCIT_C121777
http://purl.obolibrary.org/obo/NCIT_C121777
|
|---|---|
| Preferred Name | Androgen Receptor Ligand-binding Domain-encoding Plasmid DNA Vaccine MVI-118 |
| Definitions |
A cancer vaccine containing pTVG4 plasmid DNA encoding the human androgen receptor (AR) ligand-binding domain (LBD) (pTVG-AR), with potential immunostimulating and antineoplastic activities. Upon intradermal administration of AR LBD-encoding plasmid DNA vaccine MVI-118, the plasmid DNA vaccine expresses AR LBD and may stimulate the host immune system to generate a cytotoxic T-lymphocyte (CTL) response against AR LBD-expressing prostate cancer cells. This reduces proliferation of AR-expressing tumor cells. AR, a tumor-associated antigen (TAA) overexpressed in prostate cancer cells, plays a key role in the development and progression of prostate cancer; its expression is correlated with poor prognosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A cancer vaccine containing pTVG4 plasmid DNA encoding the human androgen receptor (AR) ligand-binding domain (LBD) (pTVG-AR), with potential immunostimulating and antineoplastic activities. Upon intradermal administration of AR LBD-encoding plasmid DNA vaccine MVI-118, the plasmid DNA vaccine expresses AR LBD and may stimulate the host immune system to generate a cytotoxic T-lymphocyte (CTL) response against AR LBD-expressing prostate cancer cells. This reduces proliferation of AR-expressing tumor cells. AR, a tumor-associated antigen (TAA) overexpressed in prostate cancer cells, plays a key role in the development and progression of prostate cancer; its expression is correlated with poor prognosis. |
|---|---|
| prefLabel | Androgen Receptor Ligand-binding Domain-encoding Plasmid DNA Vaccine MVI-118
|
| label | Androgen Receptor Ligand-binding Domain-encoding Plasmid DNA Vaccine MVI-118
|
| PDQ_Closed_Trial_Search_ID | 771098
|
| code | C121777
|
| prefixIRI | NCIT:C121777
|
| in_subset | |
| Preferred_Name | Androgen Receptor Ligand-binding Domain-encoding Plasmid DNA Vaccine MVI-118
|
| Maps_To | Androgen Receptor Ligand-binding Domain-encoding Plasmid DNA Vaccine MVI-118
|
| NCI_Drug_Dictionary_ID | 771098
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 771098
|
| Semantic_Type | Pharmacologic Substance
|
| UMLS_CUI | C4053487
|
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