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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1213
http://purl.obolibrary.org/obo/NCIT_C1213
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|---|---|
| Preferred Name | Rebeccamycin |
| Definitions |
An indolocarbazole glycoside antineoplastic antibiotic isolated from the bacterium Saccharothrix aerocolonigenes. Rebeccamycin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An indolocarbazole glycoside antineoplastic antibiotic isolated from the bacterium Saccharothrix aerocolonigenes. Rebeccamycin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. (NCI04) |
|---|---|
| prefLabel | Rebeccamycin
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| label | Rebeccamycin
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| CHEBI_ID | CHEBI:135511
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| code | C1213
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| prefixIRI | NCIT:C1213
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| in_subset | |
| Preferred_Name | Rebeccamycin
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| FDA_UNII_Code | Y96MQM21V9
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| Contributing_Source | FDA
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| Maps_To | Rebeccamycin
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| CAS_Registry | 93908-02-2
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| NSC Number | 359079
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| Legacy Concept Name | Rebeccamycin
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| type | |
| ALT_DEFINITION | A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antineoplastic antibiotics.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
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| UMLS_CUI | C0073012
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