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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1212
http://purl.obolibrary.org/obo/NCIT_C1212
|
|---|---|
| Preferred Name | Sirolimus |
| Definitions |
A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. (NCI04) |
|---|---|
| prefLabel | Sirolimus
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| label | Sirolimus
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| CHEBI_ID | CHEBI:9168
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| PDQ_Closed_Trial_Search_ID | 42555
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| code | C1212
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| Has_Target | |
| prefixIRI | NCIT:C1212
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| in_subset |
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| Display_Name | Sirolimus
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| Preferred_Name | Sirolimus
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| FDA_UNII_Code | W36ZG6FT64
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C51H79NO13
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| Maps_To | Sirolimus
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| CAS_Registry | 53123-88-9
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| NSC Number | 226080
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| NCI_Drug_Dictionary_ID | 42555
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| Legacy Concept Name | Sirolimus
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| type | |
| ALT_DEFINITION | A drug used to keep the body from rejecting organ and bone marrow transplants. Rapamune blocks certain white blood cells that can reject foreign tissues and organs. It also blocks a protein that is involved in cell division. It is a type of antibiotic, a type of immunosuppressant, and a type of serine/threonine kinase inhibitor. Rapamune was previously called rapamycin.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42555
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| Accepted_Therapeutic_Use_For | Kidney transplant rejection, prevention
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
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| UMLS_CUI | C0072980
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