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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C120472
http://purl.obolibrary.org/obo/NCIT_C120472
|
|---|---|
| Preferred Name | 2-Methoxyestrone |
| Definitions |
A metabolite formed during the methylation of 2-hydroxyestrone (2-OHE1) by catechol-O-methyltransferase (COMT), with potential anticarcinogenic and minimal estrogen activities. The mechanism of action for the antitumor activity of 2-methoxyestrone (2-OMeE1) is not known. A high 2-methoxyestrone (2-OMeE1)/2-OHE1 ratio indicates higher methylation efficiency and correlates with a lower cancer risk.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A metabolite formed during the methylation of 2-hydroxyestrone (2-OHE1) by catechol-O-methyltransferase (COMT), with potential anticarcinogenic and minimal estrogen activities. The mechanism of action for the antitumor activity of 2-methoxyestrone (2-OMeE1) is not known. A high 2-methoxyestrone (2-OMeE1)/2-OHE1 ratio indicates higher methylation efficiency and correlates with a lower cancer risk. |
|---|---|
| prefLabel | 2-Methoxyestrone
|
| label | 2-Methoxyestrone
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| CHEBI_ID | CHEBI:1189
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| code | C120472
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| prefixIRI | NCIT:C120472
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| in_subset |
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| Display_Name | 2-Methoxyestrone
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| Preferred_Name | 2-Methoxyestrone
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| FDA_UNII_Code | SJ5857RRL3
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| Contributing_Source |
CTRP
FDA
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| Maps_To | 2-Methoxyestrone
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| CAS_Registry | 362-08-3
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0046322
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