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Biological and Environmental Research Ontology
| Id | http://purl.obolibrary.org/obo/NCIT_C120317
http://purl.obolibrary.org/obo/NCIT_C120317
|
|---|---|
| Preferred Name | Anti-CD157 Monoclonal Antibody MEN1112 |
| Definitions |
A humanized, Fc engineered, de-fucosylated monoclonal immunoglobulin G1 (IgG1) antibody directed against the bone marrow stromal cell antigen 1 (BST1/CD157), with potential antineoplastic activity. Upon intravenous infusion, anti-CD157 monoclonal antibody MEN1112 specifically binds to and induces an antibody dependent cell cytotoxic (ADCC) response against CD157-expressing tumor cells. CD157, also known as ADP-ribosyl cyclase 2, is a glycosyl-phosphatidylinositol (GPI)-anchored transmembrane protein belonging to the ADP-ribosyl-cyclase family and is overexpressed on certain cancer cell types. Fc-optimization of MEN1112, which involves the removal of fucose residues from its Fc domain, allows for enhanced Fc-gamma receptor binding on effector cells, such as natural killer (NK) cells, and further enhances tumor cell lysis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A humanized, Fc engineered, de-fucosylated monoclonal immunoglobulin G1 (IgG1) antibody directed against the bone marrow stromal cell antigen 1 (BST1/CD157), with potential antineoplastic activity. Upon intravenous infusion, anti-CD157 monoclonal antibody MEN1112 specifically binds to and induces an antibody dependent cell cytotoxic (ADCC) response against CD157-expressing tumor cells. CD157, also known as ADP-ribosyl cyclase 2, is a glycosyl-phosphatidylinositol (GPI)-anchored transmembrane protein belonging to the ADP-ribosyl-cyclase family and is overexpressed on certain cancer cell types. Fc-optimization of MEN1112, which involves the removal of fucose residues from its Fc domain, allows for enhanced Fc-gamma receptor binding on effector cells, such as natural killer (NK) cells, and further enhances tumor cell lysis. |
|---|---|
| prefLabel | Anti-CD157 Monoclonal Antibody MEN1112
|
| label | Anti-CD157 Monoclonal Antibody MEN1112
|
| PDQ_Closed_Trial_Search_ID | 768862
|
| code | C120317
|
| prefixIRI | NCIT:C120317
|
| in_subset | |
| Preferred_Name | Anti-CD157 Monoclonal Antibody MEN1112
|
| Maps_To | Anti-CD157 Monoclonal Antibody MEN1112
|
| NCI_Drug_Dictionary_ID | 768862
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 768862
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Immunologic Factor
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| UMLS_CUI | C3896815
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