Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C120259
http://purl.obolibrary.org/obo/NCIT_C120259
Preferred Name

Palbociclib Isethionate
Definitions
The isethionate salt form of palbociclib, an orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

The isethionate salt form of palbociclib, an orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression.
prefLabel
Palbociclib Isethionate
label
Palbociclib Isethionate
code
C120259
prefixIRI
NCIT:C120259
in_subset
Display_Name
Palbociclib Isethionate
Preferred_Name
Palbociclib Isethionate
FDA_UNII_Code
W1NYL2IRDR
Contributing_Source
CTRP
FDA
Chemical_Formula
C24H29N7O2.C2-H6-O4-S
Maps_To
Palbociclib Isethionate
CAS_Registry
827022-33-3
type
Is_Value_For_GDC_Property
subClassOf
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C3896941
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