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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C120102
http://purl.obolibrary.org/obo/NCIT_C120102
|
|---|---|
| Preferred Name | Roblitinib |
| Definitions |
An inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, roblitinib binds to and inhibits the activity of FGFR4, which leads to an inhibition of tumor cell proliferation in FGFR4-overexpressing cells. FGFR4 is a receptor tyrosine kinase upregulated in certain tumor cells and involved in tumor cell proliferation, differentiation, angiogenesis, and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, roblitinib binds to and inhibits the activity of FGFR4, which leads to an inhibition of tumor cell proliferation in FGFR4-overexpressing cells. FGFR4 is a receptor tyrosine kinase upregulated in certain tumor cells and involved in tumor cell proliferation, differentiation, angiogenesis, and survival. |
|---|---|
| prefLabel | Roblitinib
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| label | Roblitinib
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| NCI_META_CUI | CL507817
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| PDQ_Closed_Trial_Search_ID | 767955
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| code | C120102
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| Has_Target | |
| prefixIRI | NCIT:C120102
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| in_subset |
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| Display_Name | Roblitinib
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| Preferred_Name | Roblitinib
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| FDA_UNII_Code | M64JF6WMSA
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| Contributing_Source |
CTRP
FDA
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| Maps_To |
FGFR4 Inhibitor FGF401
Roblitinib
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| CAS_Registry | 1708971-55-4
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| NCI_Drug_Dictionary_ID | 767955
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 767955
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| Semantic_Type | Pharmacologic Substance
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