Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C120097
http://purl.obolibrary.org/obo/NCIT_C120097
|
|---|---|
| Preferred Name | Cibisatamab |
| Definitions |
An anti-carcinoembryonic antigen (CEA)/anti-CD3 bispecific monoclonal antibody with potential antineoplastic activity. Cibisatamab contains two antigen-recognition sites: one for human CD3, a T-cell surface antigen, and one for human CEA, a tumor-associated antigen that is specifically expressed on certain tumor cells. Upon intravenous administration, cibisatamab binds to both T-cells and CEA-expressing tumor cells, which cross-links the T-cells with the tumor cells. This may result in a potent cytotoxic T-lymphocyte (CTL) response against CEA-expressing tumor cells. CEA is overexpressed in many cancer cell types.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An anti-carcinoembryonic antigen (CEA)/anti-CD3 bispecific monoclonal antibody with potential antineoplastic activity. Cibisatamab contains two antigen-recognition sites: one for human CD3, a T-cell surface antigen, and one for human CEA, a tumor-associated antigen that is specifically expressed on certain tumor cells. Upon intravenous administration, cibisatamab binds to both T-cells and CEA-expressing tumor cells, which cross-links the T-cells with the tumor cells. This may result in a potent cytotoxic T-lymphocyte (CTL) response against CEA-expressing tumor cells. CEA is overexpressed in many cancer cell types. |
|---|---|
| prefLabel | Cibisatamab
|
| label | Cibisatamab
|
| PDQ_Closed_Trial_Search_ID | 767685
|
| code | C120097
|
| Has_Target | |
| prefixIRI | NCIT:C120097
|
| in_subset |
See more
See less
|
| Display_Name | Cibisatamab
|
| Preferred_Name | Cibisatamab
|
| FDA_UNII_Code | ZAM5J1ATF2
|
| Contributing_Source |
CTRP
FDA
|
| Maps_To | Cibisatamab
|
| CAS_Registry | 1855925-27-7
|
| NCI_Drug_Dictionary_ID | 767685
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 767685
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
|
| UMLS_CUI | C3896776
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |