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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C119738
http://purl.obolibrary.org/obo/NCIT_C119738
|
|---|---|
| Preferred Name | Yttrium Y 90-DOTA-di-HSG Peptide IMP-288 |
| Definitions |
A radiolabeled divalent histamine-succinyl-glycine (HSG) hapten-peptide linked with the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to the beta-emitting radionuclide yttrium 90 (Y-90), with radioimmunotherapeutic activity. After pre-treating and targeting tumor cells with a bi-specific monoclonal antibody (BiMoAB) directed against both a tumor-associated antigen (TAA) and the HSG hapten-peptide, the HSG portion of the administered yttrium Y 90-DOTA-di-HSG peptide IMP-288 binds to the anti-HSG sequence on the BiMoAB. In turn, Y-90 delivers a cytotoxic dose of beta radiation to tumor cells expressing the specific TAA.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radiolabeled divalent histamine-succinyl-glycine (HSG) hapten-peptide linked with the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to the beta-emitting radionuclide yttrium 90 (Y-90), with radioimmunotherapeutic activity. After pre-treating and targeting tumor cells with a bi-specific monoclonal antibody (BiMoAB) directed against both a tumor-associated antigen (TAA) and the HSG hapten-peptide, the HSG portion of the administered yttrium Y 90-DOTA-di-HSG peptide IMP-288 binds to the anti-HSG sequence on the BiMoAB. In turn, Y-90 delivers a cytotoxic dose of beta radiation to tumor cells expressing the specific TAA. |
|---|---|
| prefLabel | Yttrium Y 90-DOTA-di-HSG Peptide IMP-288
|
| label | Yttrium Y 90-DOTA-di-HSG Peptide IMP-288
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| PDQ_Closed_Trial_Search_ID | 766993
|
| code | C119738
|
| prefixIRI | NCIT:C119738
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| in_subset | |
| Preferred_Name | Yttrium Y 90-DOTA-di-HSG Peptide IMP-288
|
| Maps_To | Yttrium Y 90-DOTA-di-HSG Peptide IMP-288
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| NCI_Drug_Dictionary_ID | 766993
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 766993
|
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C3896702
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