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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1197
http://purl.obolibrary.org/obo/NCIT_C1197
|
|---|---|
| Preferred Name | Pirarubicin |
| Definitions |
An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines. (NCI04) |
|---|---|
| prefLabel | Pirarubicin
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| label | Pirarubicin
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| Has_Salt_Form | |
| PDQ_Closed_Trial_Search_ID | 38775
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| code | C1197
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| prefixIRI | NCIT:C1197
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| in_subset | |
| Preferred_Name | Pirarubicin
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| FDA_UNII_Code | D58G680W0G
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| Contributing_Source | FDA
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| Chemical_Formula | C32H37NO12
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| Maps_To | Pirarubicin
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| CAS_Registry | 72496-41-4
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| NSC Number | 333054
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| NCI_Drug_Dictionary_ID | 38775
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| Legacy Concept Name | Pirarubicin
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 38775
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
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| UMLS_CUI | C0071126
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