Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C119615
http://purl.obolibrary.org/obo/NCIT_C119615
|
|---|---|
| Preferred Name | Odronextamab |
| Definitions |
A bispecific, human monoclonal antibody with potential antineoplastic activity. Anti-CD20/CD3 monoclonal antibody REGN1979 contains two antigen-recognition sites: one for human CD3, a T cell surface antigen, and one for human CD20, a tumor-associated antigen that is exclusively expressed on B-cells during most stages of B-cell development and is often overexpressed in B-cell malignancies. Upon administration, odronextamab binds to both T-cells and CD20-expressing tumor B-cells, which cross-links the T-cells to tumor cells, and may result in a potent cytotoxic T-lymphocyte (CTL) response against CD20-expressing tumor B-cells.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A bispecific, human monoclonal antibody with potential antineoplastic activity. Anti-CD20/CD3 monoclonal antibody REGN1979 contains two antigen-recognition sites: one for human CD3, a T cell surface antigen, and one for human CD20, a tumor-associated antigen that is exclusively expressed on B-cells during most stages of B-cell development and is often overexpressed in B-cell malignancies. Upon administration, odronextamab binds to both T-cells and CD20-expressing tumor B-cells, which cross-links the T-cells to tumor cells, and may result in a potent cytotoxic T-lymphocyte (CTL) response against CD20-expressing tumor B-cells. |
|---|---|
| label | Odronextamab
|
| prefLabel | Odronextamab
|
| in_subset |
See more
See less
|
| Preferred_Name | Odronextamab
|
| Is_Value_For_GDC_Property | |
| Display_Name | Odronextamab
|
| Maps_To |
Anti-CD20/CD3 Monoclonal Antibody REGN1979
Odronextamab
|
| PDQ_Open_Trial_Search_ID | 766653
|
| UMLS_CUI | C3896743
|
| FDA_UNII_Code | 8R5CM46UIO
|
| prefixIRI | NCIT:C119615
|
| NCI_Drug_Dictionary_ID | 766653
|
| Contributing_Source |
CTRP
FDA
|
| subClassOf | |
| code | C119615
|
| type | |
| PDQ_Closed_Trial_Search_ID | 766653
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
|
| CAS_Registry | 1801338-64-6
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |