Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C118953
http://purl.obolibrary.org/obo/NCIT_C118953
|
|---|---|
| Preferred Name | HER2-targeting Antibody Fc Fragment FS102 |
| Definitions |
A proprietary, antibody fragment composed of a constant (Fc) region that is engineered to bind to the tumor-associated antigen human epidermal growth factor receptor-2 (HER2), with potential antineoplastic activity. HER2-targeted antibody Fc fragment FS102 specifically binds to its HER2 epitope, and causes downregulation of HER2-mediated signaling. This leads to tumor cell apoptosis. HER2, a member of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (EGFR) superfamily, is overexpressed on the cell surface of various solid tumors.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A proprietary, antibody fragment composed of a constant (Fc) region that is engineered to bind to the tumor-associated antigen human epidermal growth factor receptor-2 (HER2), with potential antineoplastic activity. HER2-targeted antibody Fc fragment FS102 specifically binds to its HER2 epitope, and causes downregulation of HER2-mediated signaling. This leads to tumor cell apoptosis. HER2, a member of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (EGFR) superfamily, is overexpressed on the cell surface of various solid tumors. |
|---|---|
| prefLabel | HER2-targeting Antibody Fc Fragment FS102
|
| label | HER2-targeting Antibody Fc Fragment FS102
|
| PDQ_Closed_Trial_Search_ID | 766415
|
| code | C118953
|
| Has_Target | |
| prefixIRI | NCIT:C118953
|
| in_subset |
See more
See less
|
| Display_Name | HER2-targeting Antibody Fc Fragment FS102
|
| Preferred_Name | HER2-targeting Antibody Fc Fragment FS102
|
| FDA_UNII_Code | Z27ZI1MZY9
|
| Contributing_Source |
CTRP
FDA
|
| Maps_To | HER2-targeting Antibody Fc Fragment FS102
|
| NCI_Drug_Dictionary_ID | 766415
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 766415
|
| Semantic_Type | Pharmacologic Substance
|
| UMLS_CUI | C3896857
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |