Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C1188 http://purl.obolibrary.org/obo/NCIT_C1188
Preferred Name	Penclomedine
Definitions	A synthetic derivative of pyrimidine with antineoplastic activity. Penclomedine alkylates and crosslinks DNA, resulting in DNA strand breaks and inhibition of DNA and RNA synthesis. This agent is more active against tumor cells that are defective in p53 function. (NCI04)
Type	http://www.w3.org/2002/07/owl#Class

definition	A synthetic derivative of pyrimidine with antineoplastic activity. Penclomedine alkylates and crosslinks DNA, resulting in DNA strand breaks and inhibition of DNA and RNA synthesis. This agent is more active against tumor cells that are defective in p53 function. (NCI04)
prefLabel	Penclomedine
label	Penclomedine
PDQ_Closed_Trial_Search_ID	41973
code	C1188
prefixIRI	NCIT:C1188
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Preferred_Name	Penclomedine
FDA_UNII_Code	66Q80IL7CW
Contributing_Source	FDA
Chemical_Formula	C8H6Cl5NO2
Maps_To	Penclomedine
CAS_Registry	108030-77-9
NSC Number	338720
NCI_Drug_Dictionary_ID	41973
Legacy Concept Name	Penclomedine
type	http://www.w3.org/2002/07/owl#Class
ALT_DEFINITION	A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called alkylating agents.
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C746
PDQ_Open_Trial_Search_ID	41973
Semantic_Type	Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
UMLS_CUI	C0070220

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