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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C118669
http://purl.obolibrary.org/obo/NCIT_C118669
|
|---|---|
| Preferred Name | MDM2/MDMX Inhibitor ALRN-6924 |
| Definitions |
An orally available inhibitor of both murine double minute 2 (MDM2) and murine double minute X (MDMX), with potential antineoplastic activity. Upon oral administration, ALRN-6924 binds to both MDM2 and MDMX and interferes with their interaction with the transcriptional activation domain of the tumor suppressor protein p53. By preventing MDM2-p53 and MDMX-p53 interactions, p53 activity is restored, which leads to p53-mediated induction of tumor cell apoptosis. MDM2 and MDMX, negative regulators of p53 function, are often overexpressed in cancer cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally available inhibitor of both murine double minute 2 (MDM2) and murine double minute X (MDMX), with potential antineoplastic activity. Upon oral administration, ALRN-6924 binds to both MDM2 and MDMX and interferes with their interaction with the transcriptional activation domain of the tumor suppressor protein p53. By preventing MDM2-p53 and MDMX-p53 interactions, p53 activity is restored, which leads to p53-mediated induction of tumor cell apoptosis. MDM2 and MDMX, negative regulators of p53 function, are often overexpressed in cancer cells. |
|---|---|
| prefLabel | MDM2/MDMX Inhibitor ALRN-6924
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| label | MDM2/MDMX Inhibitor ALRN-6924
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| PDQ_Closed_Trial_Search_ID | 765720
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| code | C118669
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| Has_Target | |
| prefixIRI | NCIT:C118669
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| in_subset |
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| Display_Name | MDM2/MDMX Inhibitor ALRN-6924
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| Preferred_Name | MDM2/MDMX Inhibitor ALRN-6924
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| Contributing_Source | CTRP
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| Maps_To | MDM2/MDMX Inhibitor ALRN-6924
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| NCI_Drug_Dictionary_ID | 765720
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 765720
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C3896920
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