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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C118625
http://purl.obolibrary.org/obo/NCIT_C118625
|
|---|---|
| Preferred Name | Activin Type 2B Receptor Fc Fusion Protein STM 434 |
| Definitions |
A soluble fusion protein containing the extracellular domain of the activin receptor type 2B (ACVR2B or ActRIIB) fused to a human Fc domain, with potential antineoplastic activity. Upon intravenous administration, STM 434 selectively binds to the growth factor activin A, thereby preventing its binding to and the activation of endogenous ActRIIB. This prevents activin A/ActRIIB-mediated signaling and inhibits the proliferation of activin A-overexpressing tumor cells. Activin A, a member of the transforming growth factor beta (TGF-beta) superfamily, is overexpressed in a variety of cancers and plays a key role in promoting cancer cell proliferation, migration, and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A soluble fusion protein containing the extracellular domain of the activin receptor type 2B (ACVR2B or ActRIIB) fused to a human Fc domain, with potential antineoplastic activity. Upon intravenous administration, STM 434 selectively binds to the growth factor activin A, thereby preventing its binding to and the activation of endogenous ActRIIB. This prevents activin A/ActRIIB-mediated signaling and inhibits the proliferation of activin A-overexpressing tumor cells. Activin A, a member of the transforming growth factor beta (TGF-beta) superfamily, is overexpressed in a variety of cancers and plays a key role in promoting cancer cell proliferation, migration, and survival. |
|---|---|
| prefLabel | Activin Type 2B Receptor Fc Fusion Protein STM 434
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| label | Activin Type 2B Receptor Fc Fusion Protein STM 434
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| PDQ_Closed_Trial_Search_ID | 765514
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| code | C118625
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| Has_Target | |
| prefixIRI | NCIT:C118625
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| in_subset |
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| Display_Name | Activin Type 2B Receptor Fc Fusion Protein STM 434
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| Preferred_Name | Activin Type 2B Receptor Fc Fusion Protein STM 434
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| FDA_UNII_Code | 7G4D2B5AC8
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Activin Type 2B Receptor Fc Fusion Protein STM 434
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| CAS_Registry | 2055761-25-4
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| NCI_Drug_Dictionary_ID | 765514
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 765514
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C3896763
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