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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1186
http://purl.obolibrary.org/obo/NCIT_C1186
|
|---|---|
| Preferred Name | PCNU |
| Definitions |
A chloroethylnitrosourea compound and an alkylating agent with antineoplastic property. PCNU inhibits DNA synthesis by alkylating DNA and causing DNA cross links, thereby inducing apoptosis. In addition, this agent may be associated with pulmonary, hepatic, and hematologic toxicities. Unlike other nitrosoureas, PCNU has strong alkylating while weak carbamoylating activity.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A chloroethylnitrosourea compound and an alkylating agent with antineoplastic property. PCNU inhibits DNA synthesis by alkylating DNA and causing DNA cross links, thereby inducing apoptosis. In addition, this agent may be associated with pulmonary, hepatic, and hematologic toxicities. Unlike other nitrosoureas, PCNU has strong alkylating while weak carbamoylating activity. |
|---|---|
| prefLabel | PCNU
|
| label | PCNU
|
| PDQ_Closed_Trial_Search_ID | 39549
|
| code | C1186
|
| prefixIRI | NCIT:C1186
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| in_subset | |
| Preferred_Name | PCNU
|
| FDA_UNII_Code | AZW59V4Q3B
|
| Contributing_Source | FDA
|
| Maps_To | PCNU
|
| CAS_Registry | 13909-02-9
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| NSC Number | 95466
|
| NCI_Drug_Dictionary_ID | 39549
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| Legacy Concept Name | PCNU
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39549
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0070165
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