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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C118450
http://purl.obolibrary.org/obo/NCIT_C118450
|
|---|---|
| Preferred Name | Utidelone |
| Definitions |
A genetically engineered epothilone analog with potential antineoplastic activity. Upon administration, utidelone binds to tubulin, induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to first-generation epothilones, this agent exhibits greater safety and enhanced activity against certain multidrug-resistant (MDR) tumors.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A genetically engineered epothilone analog with potential antineoplastic activity. Upon administration, utidelone binds to tubulin, induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to first-generation epothilones, this agent exhibits greater safety and enhanced activity against certain multidrug-resistant (MDR) tumors. |
|---|---|
| prefLabel | Utidelone
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| label | Utidelone
|
| PDQ_Closed_Trial_Search_ID | 765129
|
| code | C118450
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| prefixIRI | NCIT:C118450
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| in_subset | |
| Preferred_Name | Utidelone
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| Maps_To | Epothilone Analog UTD1
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| NCI_Drug_Dictionary_ID | 765129
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 765129
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C3896752
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