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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C117235
http://purl.obolibrary.org/obo/NCIT_C117235
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|---|---|
| Preferred Name | IDH1R132H-Specific Peptide Vaccine PEPIDH1M |
| Definitions |
A peptide vaccine consisting of a peptide derived from isocitrate dehydrogenase 1 (IDH1) containing the point mutation R132H (IDH1R132H), with potential antineoplastic activity. Intradermal vaccination with the IDH1R132H-specific peptide vaccine PEPIDH1M may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells that express the IDH1R132H protein. The IDH1 point mutation of amino acid residue 132 is highly expressed in gliomas and is associated with increased production of the oncometabolite R-2-hydroxyglutarate (2HG).
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A peptide vaccine consisting of a peptide derived from isocitrate dehydrogenase 1 (IDH1) containing the point mutation R132H (IDH1R132H), with potential antineoplastic activity. Intradermal vaccination with the IDH1R132H-specific peptide vaccine PEPIDH1M may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells that express the IDH1R132H protein. The IDH1 point mutation of amino acid residue 132 is highly expressed in gliomas and is associated with increased production of the oncometabolite R-2-hydroxyglutarate (2HG). |
|---|---|
| prefLabel | IDH1R132H-Specific Peptide Vaccine PEPIDH1M
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| label | IDH1R132H-Specific Peptide Vaccine PEPIDH1M
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| NCI_META_CUI | CL474105
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| PDQ_Closed_Trial_Search_ID | 763159
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| code | C117235
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| Has_Target | |
| prefixIRI | NCIT:C117235
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| in_subset |
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| Display_Name | IDH1R132H-Specific Peptide Vaccine PEPIDH1M
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| Preferred_Name | IDH1R132H-Specific Peptide Vaccine PEPIDH1M
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| Contributing_Source | CTRP
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| Maps_To | IDH1R132H-Specific Peptide Vaccine PEPIDH1M
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| NCI_Drug_Dictionary_ID | 763159
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 763159
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| Semantic_Type |
Pharmacologic Substance
Immunologic Factor
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