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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C117230
http://purl.obolibrary.org/obo/NCIT_C117230
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|---|---|
| Preferred Name | pan-PI3K Inhibitor CLR457 |
| Definitions |
An orally bioavailable pan inhibitor of phosphatidylinositol-3-kinase (PI3K), with potential antineoplastic activity. Upon oral administration, pan-PI3K inhibitor CLR457 inhibits all of the PI3K kinase isoforms, which may result in apoptosis and growth inhibition in tumor cells overexpressing PI3K. Activation of the PI3K pathway promotes cell growth, survival, and resistance to both chemotherapy and radiotherapy.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable pan inhibitor of phosphatidylinositol-3-kinase (PI3K), with potential antineoplastic activity. Upon oral administration, pan-PI3K inhibitor CLR457 inhibits all of the PI3K kinase isoforms, which may result in apoptosis and growth inhibition in tumor cells overexpressing PI3K. Activation of the PI3K pathway promotes cell growth, survival, and resistance to both chemotherapy and radiotherapy. |
|---|---|
| prefLabel | pan-PI3K Inhibitor CLR457
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| label | pan-PI3K Inhibitor CLR457
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| NCI_META_CUI | CL474098
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| PDQ_Closed_Trial_Search_ID | 763082
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| code | C117230
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| Has_Target | |
| prefixIRI | NCIT:C117230
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| in_subset | |
| Preferred_Name | pan-PI3K Inhibitor CLR457
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| Maps_To | pan-PI3K Inhibitor CLR457
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| NCI_Drug_Dictionary_ID | 763082
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 763082
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| Semantic_Type | Pharmacologic Substance
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