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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C116873
http://purl.obolibrary.org/obo/NCIT_C116873
|
|---|---|
| Preferred Name | STAT Inhibitor OPB-111077 |
| Definitions |
An orally bioavailable inhibitor of one or more signal transducer and activator of transcription (STAT) protein(s), with potential antineoplastic activity. Upon oral administration, OPB-111077 binds to and inhibits the phosphorylation of STATs. This prevents binding of STATs to DNA sequences on a variety of STAT-responsive gene promoters, which may result in the inhibition of both STAT-mediated transcription and tumor cell proliferation. STATs are constitutively activated in a variety of cancers and play a key role in tumor cell proliferation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable inhibitor of one or more signal transducer and activator of transcription (STAT) protein(s), with potential antineoplastic activity. Upon oral administration, OPB-111077 binds to and inhibits the phosphorylation of STATs. This prevents binding of STATs to DNA sequences on a variety of STAT-responsive gene promoters, which may result in the inhibition of both STAT-mediated transcription and tumor cell proliferation. STATs are constitutively activated in a variety of cancers and play a key role in tumor cell proliferation. |
|---|---|
| prefLabel | STAT Inhibitor OPB-111077
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| label | STAT Inhibitor OPB-111077
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| NCI_META_CUI | CL446660
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| PDQ_Closed_Trial_Search_ID | 742040
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| code | C116873
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| Has_Target | |
| prefixIRI | NCIT:C116873
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| in_subset |
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| Display_Name | STAT Inhibitor OPB-111077
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| Preferred_Name | STAT Inhibitor OPB-111077
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| Contributing_Source | CTRP
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| Maps_To | STAT Inhibitor OPB-111077
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| NCI_Drug_Dictionary_ID | 742040
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 742040
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| Semantic_Type | Pharmacologic Substance
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