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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C116861
http://purl.obolibrary.org/obo/NCIT_C116861
|
|---|---|
| Preferred Name | Pan-RAF Inhibitor LY3009120 |
| Definitions |
An orally available inhibitor of all members of the serine/threonine protein kinase Raf family, including A-Raf, B-Raf and C-Raf protein kinases, with potential antineoplastic activity. Upon administration, pan-RAF kinase inhibitor LY3009120 inhibits Raf-mediated signal transduction pathways, which may inhibit tumor cell growth. Raf protein kinases play a key role in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway, which is often dysregulated in human cancers and plays a key role in tumor cell proliferation and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally available inhibitor of all members of the serine/threonine protein kinase Raf family, including A-Raf, B-Raf and C-Raf protein kinases, with potential antineoplastic activity. Upon administration, pan-RAF kinase inhibitor LY3009120 inhibits Raf-mediated signal transduction pathways, which may inhibit tumor cell growth. Raf protein kinases play a key role in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway, which is often dysregulated in human cancers and plays a key role in tumor cell proliferation and survival. |
|---|---|
| prefLabel | Pan-RAF Inhibitor LY3009120
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| label | Pan-RAF Inhibitor LY3009120
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| PDQ_Closed_Trial_Search_ID | 756062
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| code | C116861
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| Has_Target | |
| prefixIRI | NCIT:C116861
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| in_subset |
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| Display_Name | Pan-RAF Inhibitor LY3009120
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| Preferred_Name | Pan-RAF Inhibitor LY3009120
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| FDA_UNII_Code | 1GDT36RARO
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Pan-RAF Inhibitor LY3009120
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| CAS_Registry | 1454682-72-4
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| NCI_Drug_Dictionary_ID | 756062
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 756062
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C3896821
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