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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C116860
http://purl.obolibrary.org/obo/NCIT_C116860
|
|---|---|
| Preferred Name | Porcupine Inhibitor WNT974 |
| Definitions |
An orally available inhibitor of porcupine (PORCN), with potential antineoplastic activity. Upon oral administration, WNT974 binds to and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational acylation of Wnt ligands and inhibits their secretion. This prevents the activation of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in Wnt-driven tumors. Porcupine, a membrane-bound O-acyltransferase (MBOAT), is required for the palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion and activity. Wnt signaling is dysregulated in a variety of cancers.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally available inhibitor of porcupine (PORCN), with potential antineoplastic activity. Upon oral administration, WNT974 binds to and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational acylation of Wnt ligands and inhibits their secretion. This prevents the activation of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in Wnt-driven tumors. Porcupine, a membrane-bound O-acyltransferase (MBOAT), is required for the palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion and activity. Wnt signaling is dysregulated in a variety of cancers. |
|---|---|
| prefLabel | Porcupine Inhibitor WNT974
|
| label | Porcupine Inhibitor WNT974
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| PDQ_Closed_Trial_Search_ID | 700477
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| code | C116860
|
| Has_Target | |
| prefixIRI | NCIT:C116860
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| in_subset |
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| Display_Name | Porcupine Inhibitor WNT974
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| Preferred_Name | Porcupine Inhibitor WNT974
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| FDA_UNII_Code | U27F40013Q
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Porcupine Inhibitor WNT974
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| CAS_Registry | 1243244-14-5
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| NCI_Drug_Dictionary_ID | 700477
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 700477
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C3851400
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