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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C116744
http://purl.obolibrary.org/obo/NCIT_C116744
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|---|---|
| Preferred Name | Nucleoside Analog DFP-10917 |
| Definitions |
A deoxycytosine analog with potential antineoplastic activity. Upon administration, DFP-10917 is phosphorylated to generate its nucleotide form that functions as a deoxycytosine mimic and is incorporated into DNA in tumor cells. This causes DNA strand breaks during polymerization due to beta-elimination during the fidelity checkpoint, which results in G2/M phase-arrest and tumor cell apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A deoxycytosine analog with potential antineoplastic activity. Upon administration, DFP-10917 is phosphorylated to generate its nucleotide form that functions as a deoxycytosine mimic and is incorporated into DNA in tumor cells. This causes DNA strand breaks during polymerization due to beta-elimination during the fidelity checkpoint, which results in G2/M phase-arrest and tumor cell apoptosis. |
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| prefLabel | Nucleoside Analog DFP-10917
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| label | Nucleoside Analog DFP-10917
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| PDQ_Closed_Trial_Search_ID | 741505
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| code | C116744
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| prefixIRI | NCIT:C116744
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| in_subset |
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| Display_Name | Nucleoside Analog DFP-10917
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| Preferred_Name | Nucleoside Analog DFP-10917
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| Contributing_Source | CTRP
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| Maps_To | Nucleoside Analog DFP-10917
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| NCI_Drug_Dictionary_ID | 741505
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 741505
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0091023
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