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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C116728
http://purl.obolibrary.org/obo/NCIT_C116728
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|---|---|
| Preferred Name | iNOS Dimerization Inhibitor FK-330 |
| Definitions |
An orally bioavailable small molecule inhibitor of inducible nitric oxide synthase (iNOS) with potential antineoplastic activity. Upon administration, iNOS Dimerization Inhibitor FK-330 inhibits iNOS dimerization, which results in decreased nitric oxide (NO) production. iNOS expression is upregulated in certain cancers and may invoke a chronic inflammatory state in tumor cells that promotes metastatic growth.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable small molecule inhibitor of inducible nitric oxide synthase (iNOS) with potential antineoplastic activity. Upon administration, iNOS Dimerization Inhibitor FK-330 inhibits iNOS dimerization, which results in decreased nitric oxide (NO) production. iNOS expression is upregulated in certain cancers and may invoke a chronic inflammatory state in tumor cells that promotes metastatic growth. |
|---|---|
| prefLabel | iNOS Dimerization Inhibitor FK-330
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| label | iNOS Dimerization Inhibitor FK-330
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| PDQ_Closed_Trial_Search_ID | 741936
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| code | C116728
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| Has_Target | |
| prefixIRI | NCIT:C116728
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| in_subset |
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| Display_Name | iNOS Dimerization Inhibitor ASP9853
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| Preferred_Name | iNOS Dimerization Inhibitor FK-330
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| FDA_UNII_Code | K47C68D94B
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| Contributing_Source |
CTRP
FDA
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| Maps_To | iNOS Dimerization Inhibitor ASP9853
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| CAS_Registry | 442198-67-6
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| NCI_Drug_Dictionary_ID | 741936
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 741936
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C3900153
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