Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C116619
http://purl.obolibrary.org/obo/NCIT_C116619
Preferred Name

Utomilumab
Definitions
A human, agonistic immunoglobulin (Ig) G2 monoclonal antibody (mAb) targeting 4-1BB (CD137, TNFRSF9), with potential immunostimulating activity. Upon administration, utomilumab binds to and activates 4-1BB expressed on various immune cells, such as CD8-positive and CD4-positive T cells and natural killer (NK) cells. This enhances 4-1BB-mediated signaling, induces cytokine production and promotes anti-tumor immune responses. 4-1BB, a member of the tumor necrosis factor (TNF)/nerve growth factor (NGF) family of receptors, plays an important role in the regulation of immune responses.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A human, agonistic immunoglobulin (Ig) G2 monoclonal antibody (mAb) targeting 4-1BB (CD137, TNFRSF9), with potential immunostimulating activity. Upon administration, utomilumab binds to and activates 4-1BB expressed on various immune cells, such as CD8-positive and CD4-positive T cells and natural killer (NK) cells. This enhances 4-1BB-mediated signaling, induces cytokine production and promotes anti-tumor immune responses. 4-1BB, a member of the tumor necrosis factor (TNF)/nerve growth factor (NGF) family of receptors, plays an important role in the regulation of immune responses.
label
Utomilumab
prefLabel
Utomilumab
in_subset
Preferred_Name
Utomilumab
Is_Value_For_GDC_Property
Display_Name
Utomilumab
Maps_To
Utomilumab
PDQ_Open_Trial_Search_ID
696781
Has_Target
UMLS_CUI
C3529795
FDA_UNII_Code
6YY8O697VF
prefixIRI
NCIT:C116619
NCI_Drug_Dictionary_ID
696781
Contributing_Source
CTRP
FDA
subClassOf
code
C116619
type
PDQ_Closed_Trial_Search_ID
696781
Semantic_Type
Amino Acid, Peptide, or Protein
Pharmacologic Substance
CAS_Registry
1417318-27-4
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