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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1165
http://purl.obolibrary.org/obo/NCIT_C1165
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|---|---|
| Preferred Name | 2-Ethylhydrazide |
| Definitions |
A podophyllic acid derivative of podophyllotoxin, a substance extracted from the mandrake root Podophyllum peltatum. Possessing potent antineoplastic properties, 2-ethylhydrazide binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A podophyllic acid derivative of podophyllotoxin, a substance extracted from the mandrake root Podophyllum peltatum. Possessing potent antineoplastic properties, 2-ethylhydrazide binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. |
|---|---|
| label | 2-Ethylhydrazide
|
| prefLabel | 2-Ethylhydrazide
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| Legacy Concept Name | _2-Ethylhydrazide
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| in_subset | |
| Preferred_Name | 2-Ethylhydrazide
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| Is_Value_For_GDC_Property | |
| Maps_To | 2-Ethylhydrazide
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| UMLS_CUI | C0066615
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| prefixIRI | NCIT:C1165
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| subClassOf | |
| code | C1165
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| type | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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