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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C116351
http://purl.obolibrary.org/obo/NCIT_C116351
|
|---|---|
| Preferred Name | PI3K/mTORC1/mTORC2 Inhibitor DCBCI0901 |
| Definitions |
An inhibitor of phosphatidylinositide 3-kinase (PI3K), raptor-mTOR (mTOR complex 1 or mTORC1) and rictor-mTOR (mTOR complex 2 or mTORC2) with potential antineoplastic activity. Upon intravenous infusion, PI3K/mTORC1/mTORC2 inhibitor DCBCI0901 binds to and inhibits PI3K as well as both mTORC1 and mTORC2, which may result in both apoptosis and a decrease in cell proliferation in tumor cells overexpressing PI3K, mTORC1, and mTORC2. Activation of the PI3K/mTOR signaling pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An inhibitor of phosphatidylinositide 3-kinase (PI3K), raptor-mTOR (mTOR complex 1 or mTORC1) and rictor-mTOR (mTOR complex 2 or mTORC2) with potential antineoplastic activity. Upon intravenous infusion, PI3K/mTORC1/mTORC2 inhibitor DCBCI0901 binds to and inhibits PI3K as well as both mTORC1 and mTORC2, which may result in both apoptosis and a decrease in cell proliferation in tumor cells overexpressing PI3K, mTORC1, and mTORC2. Activation of the PI3K/mTOR signaling pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K. |
|---|---|
| prefLabel | PI3K/mTORC1/mTORC2 Inhibitor DCBCI0901
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| label | PI3K/mTORC1/mTORC2 Inhibitor DCBCI0901
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| NCI_META_CUI | CL473670
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| PDQ_Closed_Trial_Search_ID | 761750
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| code | C116351
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| prefixIRI | NCIT:C116351
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| in_subset | |
| Preferred_Name | PI3K/mTORC1/mTORC2 Inhibitor DCBCI0901
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| Maps_To | PI3K/mTORC1/mTORC2 Inhibitor DCBCI0901
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| NCI_Drug_Dictionary_ID | 761750
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 761750
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| Semantic_Type | Pharmacologic Substance
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