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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C116326
http://purl.obolibrary.org/obo/NCIT_C116326
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|---|---|
| Preferred Name | Androgen Receptor Antisense Oligonucleotide AZD5312 |
| Definitions |
An antisense oligonucleotide targeting the androgen receptor (AR) mRNA, with potential antineoplastic activity. Upon intravenous administration, AZD5312 hybridizes with AR mRNA, which blocks translation of the AR protein. This both inhibits AR-induced tumor cell growth and promotes apoptosis in AR-overexpressing tumor cells. AR is overexpressed in certain breast and prostate cancers and is involved in tumor cell proliferation and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An antisense oligonucleotide targeting the androgen receptor (AR) mRNA, with potential antineoplastic activity. Upon intravenous administration, AZD5312 hybridizes with AR mRNA, which blocks translation of the AR protein. This both inhibits AR-induced tumor cell growth and promotes apoptosis in AR-overexpressing tumor cells. AR is overexpressed in certain breast and prostate cancers and is involved in tumor cell proliferation and survival. |
|---|---|
| prefLabel | Androgen Receptor Antisense Oligonucleotide AZD5312
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| label | Androgen Receptor Antisense Oligonucleotide AZD5312
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| NCI_META_CUI | CL473660
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| PDQ_Closed_Trial_Search_ID | 761561
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| code | C116326
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| Has_Target | |
| prefixIRI | NCIT:C116326
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| in_subset |
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| Display_Name | Androgen Receptor Antisense Oligonucleotide AZD5312
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| Preferred_Name | Androgen Receptor Antisense Oligonucleotide AZD5312
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| FDA_UNII_Code | 3S31QX1Q6J
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Androgen Receptor Antisense Oligonucleotide AZD5312
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| NCI_Drug_Dictionary_ID | 761561
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 761561
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| Delete | Subject | Author | Type | Created |
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