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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1161
http://purl.obolibrary.org/obo/NCIT_C1161
|
|---|---|
| Preferred Name | Metoprine |
| Definitions |
A diaminopyrimidine folate antagonist with potential antineoplastic activity. Metoprine inhibits dihydrofolate reductase, resulting in decreased cellular folate metabolism and cell growth; it also inhibits histamine-N-methyltransferase, resulting in decreased histamine catabolism. Lipid-soluble metoprine is capable of crossing the blood-brain barrier. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A diaminopyrimidine folate antagonist with potential antineoplastic activity. Metoprine inhibits dihydrofolate reductase, resulting in decreased cellular folate metabolism and cell growth; it also inhibits histamine-N-methyltransferase, resulting in decreased histamine catabolism. Lipid-soluble metoprine is capable of crossing the blood-brain barrier. (NCI04) |
|---|---|
| label | Metoprine
|
| prefLabel | Metoprine
|
| Legacy Concept Name | Metoprine
|
| in_subset | |
| Preferred_Name | Metoprine
|
| Is_Value_For_GDC_Property | |
| Chemical_Formula | C11H10Cl2N4
|
| Maps_To | Metoprine
|
| PDQ_Open_Trial_Search_ID | 39206
|
| UMLS_CUI | C0066142
|
| FDA_UNII_Code | 2L9RKX796Q
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| prefixIRI | NCIT:C1161
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| NCI_Drug_Dictionary_ID | 39206
|
| Contributing_Source | FDA
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| subClassOf | |
| code | C1161
|
| type | |
| NSC Number |
19494
7364
|
| PDQ_Closed_Trial_Search_ID | 39206
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| CAS_Registry | 7761-45-7
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| Delete | Subject | Author | Type | Created |
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