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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1152
http://purl.obolibrary.org/obo/NCIT_C1152
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|---|---|
| Preferred Name | Marcellomycin |
| Definitions |
An antineoplastic oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Actinosporangium bohemicum. Marcellomycin intercalates into DNA and induces DNA crosslinks, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also induces differentiation in HL-60 promyelocytic leukemia cells by interfering with glycoprotein synthesis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An antineoplastic oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Actinosporangium bohemicum. Marcellomycin intercalates into DNA and induces DNA crosslinks, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also induces differentiation in HL-60 promyelocytic leukemia cells by interfering with glycoprotein synthesis. (NCI04) |
|---|---|
| prefLabel | Marcellomycin
|
| label | Marcellomycin
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| PDQ_Closed_Trial_Search_ID | 39758
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| code | C1152
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| prefixIRI | NCIT:C1152
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| in_subset | |
| Preferred_Name | Marcellomycin
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| FDA_UNII_Code | 3296X8L13E
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| Contributing_Source | FDA
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| Maps_To | Marcellomycin
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| CAS_Registry | 63710-10-1
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| NSC Number | 265211
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| NCI_Drug_Dictionary_ID | 39758
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| Legacy Concept Name | Marcellomycin
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39758
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
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| UMLS_CUI | C0065718
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