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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C115111
http://purl.obolibrary.org/obo/NCIT_C115111
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|---|---|
| Preferred Name | Belapectin |
| Definitions |
A carbohydrate-based galectin inhibitor, with potential antineoplastic activity. Belapectin binds to the carbohydrate-binding domain of galectins, especially galectin-3, and may result in an induction of apoptosis mediated through activation of both mitochondria and caspases. This may reduce tumor growth in galectin-overexpressing tumor cells. Galectins, often overexpressed on tumor cells, play a key role in cancer cell proliferation, apoptosis, tumor angiogenesis and evasion of immune responses.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A carbohydrate-based galectin inhibitor, with potential antineoplastic activity. Belapectin binds to the carbohydrate-binding domain of galectins, especially galectin-3, and may result in an induction of apoptosis mediated through activation of both mitochondria and caspases. This may reduce tumor growth in galectin-overexpressing tumor cells. Galectins, often overexpressed on tumor cells, play a key role in cancer cell proliferation, apoptosis, tumor angiogenesis and evasion of immune responses. |
|---|---|
| label | Belapectin
|
| prefLabel | Belapectin
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| in_subset |
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| Preferred_Name | Belapectin
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| Is_Value_For_GDC_Property | |
| Display_Name | Belapectin
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| Maps_To |
Galectin Inhibitor GR-MD-02
Belapectin
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| PDQ_Open_Trial_Search_ID | 760131
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| Has_Target | |
| FDA_UNII_Code | K7ODU55HT6
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| prefixIRI | NCIT:C115111
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| NCI_Drug_Dictionary_ID | 760131
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| Contributing_Source |
CTRP
FDA
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| subClassOf | |
| code | C115111
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| type | |
| PDQ_Closed_Trial_Search_ID | 760131
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| CAS_Registry | 1980787-47-0
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| NCI_META_CUI | CL472642
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| Delete | Subject | Author | Type | Created |
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