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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1150
http://purl.obolibrary.org/obo/NCIT_C1150
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|---|---|
| Preferred Name | Mafosfamide |
| Definitions |
A synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis. Although closely related to cyclophosphamide, mafosfamide, unlike cyclophosphamide, does not require hepatic activation to generate its active metabolite 4-hydroxy-cyclophosphamide; accordingly, mafosfamide is potentially useful in the intrathecal treatment of neoplastic meningitis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis. Although closely related to cyclophosphamide, mafosfamide, unlike cyclophosphamide, does not require hepatic activation to generate its active metabolite 4-hydroxy-cyclophosphamide; accordingly, mafosfamide is potentially useful in the intrathecal treatment of neoplastic meningitis. (NCI04) |
|---|---|
| prefLabel | Mafosfamide
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| label | Mafosfamide
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| PDQ_Closed_Trial_Search_ID | 41254
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| code | C1150
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| prefixIRI | NCIT:C1150
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| in_subset | |
| Preferred_Name | Mafosfamide
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| FDA_UNII_Code | 5970HH9923
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| Contributing_Source | FDA
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| Chemical_Formula | C9H19Cl2N2O5PS2
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| Maps_To | Mafosfamide
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| CAS_Registry | 88859-04-5
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| NSC Number | 345842
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| NCI_Drug_Dictionary_ID | 41254
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| Legacy Concept Name | Mafosfamide
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| type | |
| ALT_DEFINITION | A form of cyclophosphamide that can be administered as an intrathecal infusion. Mafosfamide is being studied as an anticancer drug. It belongs to the family of drugs called alkylating agents.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41254
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0065506
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