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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C114499
http://purl.obolibrary.org/obo/NCIT_C114499
|
|---|---|
| Preferred Name | Lutetium Lu 177 PP-F11N |
| Definitions |
A radioconjugate composed of PP-F11N, a gastrin analog, conjugated to the beta-emitting radioisotope lutetium Lu 177, with potential antineoplastic activity and potential use as an imaging agent for scintigraphy. Following intravenous administration, the PP-F11N moiety binds to the cholecystokinin-2 (CCK-2) receptor. Subsequently, the CCK-2 receptor-expressing tumor cells can be visualized scintigraphically. In addition, the radioisotope moiety delivers a cytotoxic dose of beta radiation to CCK-2 receptor-expressing tumor cells. CCK-2 receptors are expressed on a variety of tumor cell types.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radioconjugate composed of PP-F11N, a gastrin analog, conjugated to the beta-emitting radioisotope lutetium Lu 177, with potential antineoplastic activity and potential use as an imaging agent for scintigraphy. Following intravenous administration, the PP-F11N moiety binds to the cholecystokinin-2 (CCK-2) receptor. Subsequently, the CCK-2 receptor-expressing tumor cells can be visualized scintigraphically. In addition, the radioisotope moiety delivers a cytotoxic dose of beta radiation to CCK-2 receptor-expressing tumor cells. CCK-2 receptors are expressed on a variety of tumor cell types. |
|---|---|
| prefLabel | Lutetium Lu 177 PP-F11N
|
| label | Lutetium Lu 177 PP-F11N
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| NCI_META_CUI | CL472324
|
| PDQ_Closed_Trial_Search_ID | 759373
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| code | C114499
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| prefixIRI | NCIT:C114499
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| in_subset | |
| Preferred_Name | Lutetium Lu 177 PP-F11N
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| FDA_UNII_Code | 639NVQ0SXF
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| Contributing_Source | FDA
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| Maps_To | Lutetium Lu 177 PP-F11N
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| CAS_Registry | 1771736-69-6
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| NCI_Drug_Dictionary_ID | 759373
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 759373
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| Semantic_Type | Pharmacologic Substance
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