Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1141
http://purl.obolibrary.org/obo/NCIT_C1141
Preferred Name

Carboxyamidotriazole
Definitions
An orally-active agent with potential antineoplastic activity. Carboxyamidotriazole binds to and inhibits non-voltage-operated Ca2+ channels, blocking both Ca2+ influx into cells and Ca2+ release from intracellular stores and resulting in the disruption of calcium channel-mediated signal transduction and inhibition of vascular endothelial growth factor (VEGF) signaling, endothelial proliferation, and angiogenesis. This agent may also inhibit tumor cell growth, invasion and metastasis. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

An orally-active agent with potential antineoplastic activity. Carboxyamidotriazole binds to and inhibits non-voltage-operated Ca2+ channels, blocking both Ca2+ influx into cells and Ca2+ release from intracellular stores and resulting in the disruption of calcium channel-mediated signal transduction and inhibition of vascular endothelial growth factor (VEGF) signaling, endothelial proliferation, and angiogenesis. This agent may also inhibit tumor cell growth, invasion and metastasis. (NCI04)
prefLabel
Carboxyamidotriazole
label
Carboxyamidotriazole
PDQ_Closed_Trial_Search_ID
41613
code
C1141
Has_Target
prefixIRI
NCIT:C1141
in_subset
Display_Name
Carboxyamidotriazole
Preferred_Name
Carboxyamidotriazole
FDA_UNII_Code
6ST3ZF52WB
Contributing_Source
CTRP
FDA
Maps_To
Carboxyamidotriazole
CAS_Registry
99519-84-3
NSC Number
609974
NCI_Drug_Dictionary_ID
41613
Legacy Concept Name
Carboxyamidotriazole
type
ALT_DEFINITION
An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
41613
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0064494
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