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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C113801
http://purl.obolibrary.org/obo/NCIT_C113801
|
|---|---|
| Preferred Name | Lutetium Lu 177 DOTA-biotin |
| Definitions |
A radioconjugate of biotin conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and labeled with the beta-emitting isotope lutetium Lu 177 (Lu-177) that can be used for radioimmunotherapeutic purposes. Lutetium Lu 177 DOTA-biotin could be used in pre-targeting radioimmunotherapy, which pretreats the lesion with oxidized avidin that binds to protein amino groups on cells. As avidin binds to biotin, the radioisotope can be selectively delivered to cancer cells leading to tumor cell eradication.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radioconjugate of biotin conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and labeled with the beta-emitting isotope lutetium Lu 177 (Lu-177) that can be used for radioimmunotherapeutic purposes. Lutetium Lu 177 DOTA-biotin could be used in pre-targeting radioimmunotherapy, which pretreats the lesion with oxidized avidin that binds to protein amino groups on cells. As avidin binds to biotin, the radioisotope can be selectively delivered to cancer cells leading to tumor cell eradication. |
|---|---|
| prefLabel | Lutetium Lu 177 DOTA-biotin
|
| label | Lutetium Lu 177 DOTA-biotin
|
| NCI_META_CUI | CL471782
|
| PDQ_Closed_Trial_Search_ID | 757658
|
| code | C113801
|
| prefixIRI | NCIT:C113801
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| in_subset | |
| Preferred_Name | Lutetium Lu 177 DOTA-biotin
|
| FDA_UNII_Code | 5U8L0A8I80
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| Contributing_Source | FDA
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| Maps_To | Lutetium Lu 177 DOTA-biotin
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| NCI_Drug_Dictionary_ID | 757658
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 757658
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| Semantic_Type | Pharmacologic Substance
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