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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1138
http://purl.obolibrary.org/obo/NCIT_C1138
|
|---|---|
| Preferred Name | Itraconazole |
| Definitions |
A synthetic triazole agent with antimycotic properties. Formulated for both topical and systemic use, itraconazole preferentially inhibits fungal cytochrome P450 enzymes, resulting in a decrease in fungal ergosterol synthesis. Because of its low toxicity profile, this agent can be used for long-term maintenance treatment of chronic fungal infections. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic triazole agent with antimycotic properties. Formulated for both topical and systemic use, itraconazole preferentially inhibits fungal cytochrome P450 enzymes, resulting in a decrease in fungal ergosterol synthesis. Because of its low toxicity profile, this agent can be used for long-term maintenance treatment of chronic fungal infections. (NCI04) |
|---|---|
| label | Itraconazole
|
| prefLabel | Itraconazole
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| Legacy Concept Name | Itraconazole
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| in_subset |
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| Preferred_Name | Itraconazole
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| Is_Value_For_GDC_Property | |
| Chemical_Formula | C35H38Cl2N8O4
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| Display_Name | Itraconazole
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| Maps_To | Itraconazole
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| PDQ_Open_Trial_Search_ID | 39106
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| UMLS_CUI | C0064113
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| FDA_UNII_Code | 304NUG5GF4
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| prefixIRI | NCIT:C1138
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| Accepted_Therapeutic_Use_For | Fungal Infections
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| NCI_Drug_Dictionary_ID | 39106
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| Contributing_Source |
CTRP
FDA
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| subClassOf | |
| CHEBI_ID | CHEBI:6076
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| code | C1138
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| type | |
| ALT_DEFINITION | A drug used to prevent or treat fungal infections. It belongs to the family of drugs called antifungal agents.
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| PDQ_Closed_Trial_Search_ID | 39106
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
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| CAS_Registry | 84625-61-6
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| Delete | Subject | Author | Type | Created |
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