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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C113795
http://purl.obolibrary.org/obo/NCIT_C113795
|
|---|---|
| Preferred Name | Immediate-release Onapristone |
| Definitions |
An immediate-release (IR) formulation of onapristone, an orally bioavailable progesterone receptor (PR) antagonist, with antineoplastic activity. Onapristone binds to the PR and inhibits both PR activation and the associated expression of PR-responsive genes. This may inhibit PR-mediated proliferative effects in cancer cells overexpressing PR. PR is expressed on certain cancer cell types and plays a key role in proliferation and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An immediate-release (IR) formulation of onapristone, an orally bioavailable progesterone receptor (PR) antagonist, with antineoplastic activity. Onapristone binds to the PR and inhibits both PR activation and the associated expression of PR-responsive genes. This may inhibit PR-mediated proliferative effects in cancer cells overexpressing PR. PR is expressed on certain cancer cell types and plays a key role in proliferation and survival. |
|---|---|
| prefLabel | Immediate-release Onapristone
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| label | Immediate-release Onapristone
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| NCI_META_CUI | CL471777
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| PDQ_Closed_Trial_Search_ID | 757590
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| code | C113795
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| prefixIRI | NCIT:C113795
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| in_subset | |
| Preferred_Name | Immediate-release Onapristone
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| Maps_To | Immediate-release Onapristone
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| NCI_Drug_Dictionary_ID | 757590
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 757590
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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