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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C113646
http://purl.obolibrary.org/obo/NCIT_C113646
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|---|---|
| Preferred Name | LSD1 Inhibitor GSK2879552 |
| Definitions |
An orally available, irreversible, inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity. Upon administration, GSK2879552 binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the dimethylated form of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor-suppressor genes. This may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. LSD1, overexpressed in certain tumor cells, plays a key role in tumor cell growth and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally available, irreversible, inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity. Upon administration, GSK2879552 binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the dimethylated form of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor-suppressor genes. This may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. LSD1, overexpressed in certain tumor cells, plays a key role in tumor cell growth and survival. |
|---|---|
| prefLabel | LSD1 Inhibitor GSK2879552
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| label | LSD1 Inhibitor GSK2879552
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| PDQ_Closed_Trial_Search_ID | 756742
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| code | C113646
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| Has_Target | |
| prefixIRI | NCIT:C113646
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| in_subset |
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| Display_Name | LSD1 Inhibitor GSK2879552
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| Preferred_Name | LSD1 Inhibitor GSK2879552
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| Contributing_Source | CTRP
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| Maps_To | LSD1 Inhibitor GSK2879552
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| NCI_Drug_Dictionary_ID | 756742
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 756742
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C3827120
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