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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C113434
http://purl.obolibrary.org/obo/NCIT_C113434
|
|---|---|
| Preferred Name | Parsaclisib |
| Definitions |
An inhibitor of the delta isoform of phosphoinositide-3 kinase (PI3K) with potential antineoplastic activity. Parsaclisib inhibits the delta isoform of PI3K and prevents the activation of the PI3K/AKT signaling pathway. This both decreases proliferation and induces cell death in PI3K-delta-overexpressing tumor cells. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic disease and cell lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An inhibitor of the delta isoform of phosphoinositide-3 kinase (PI3K) with potential antineoplastic activity. Parsaclisib inhibits the delta isoform of PI3K and prevents the activation of the PI3K/AKT signaling pathway. This both decreases proliferation and induces cell death in PI3K-delta-overexpressing tumor cells. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic disease and cell lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival. |
|---|---|
| label | Parsaclisib
|
| prefLabel | Parsaclisib
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| in_subset |
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| Preferred_Name | Parsaclisib
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| Is_Value_For_GDC_Property | |
| Display_Name | Parsaclisib
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| Maps_To |
PI3K-delta Inhibitor INCB050465
Parsaclisib
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| PDQ_Open_Trial_Search_ID | 756266
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| Has_Target | |
| FDA_UNII_Code | OS7097575K
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| prefixIRI | NCIT:C113434
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| NCI_Drug_Dictionary_ID | 756266
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| Contributing_Source |
CTRP
FDA
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| subClassOf | |
| code | C113434
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| type | |
| PDQ_Closed_Trial_Search_ID | 756266
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| Semantic_Type | Pharmacologic Substance
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| CAS_Registry | 1426698-88-5
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| NCI_META_CUI | CL458228
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