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Biological and Environmental Research Ontology
| Id | http://purl.obolibrary.org/obo/NCIT_C113432
http://purl.obolibrary.org/obo/NCIT_C113432
|
|---|---|
| Preferred Name | NY-ESO-1/GLA-SE Vaccine ID-G305 |
| Definitions |
A cancer vaccine composed of a recombinant form of the tumor antigen NY-ESO-1 and glucopyranosyl lipid adjuvant (GLA)-stable emulsion (GLA-SE), with potential antineoplastic and immunomodulating activities. Upon intramuscular injection, the adjuvant portion of the NY-ESO-1/GLA-SE vaccine ID-G30 binds to toll-like receptor subtype 4 (TLR-4) expressed on dendritic cells (DCs), monocytes, macrophages and B cells. The activated DCs present the NY-ESO-1 antigen to Th1 CD4 T-lymphocytes. This leads to the induction of cytotoxic T lymphocytes (CTLs) and the killing of NY-ESO-1-expressing tumor cells. This vaccine also induces specific antibody responses and increases the production of inflammatory cytokines.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A cancer vaccine composed of a recombinant form of the tumor antigen NY-ESO-1 and glucopyranosyl lipid adjuvant (GLA)-stable emulsion (GLA-SE), with potential antineoplastic and immunomodulating activities. Upon intramuscular injection, the adjuvant portion of the NY-ESO-1/GLA-SE vaccine ID-G30 binds to toll-like receptor subtype 4 (TLR-4) expressed on dendritic cells (DCs), monocytes, macrophages and B cells. The activated DCs present the NY-ESO-1 antigen to Th1 CD4 T-lymphocytes. This leads to the induction of cytotoxic T lymphocytes (CTLs) and the killing of NY-ESO-1-expressing tumor cells. This vaccine also induces specific antibody responses and increases the production of inflammatory cytokines. |
|---|---|
| prefLabel | NY-ESO-1/GLA-SE Vaccine ID-G305
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| label | NY-ESO-1/GLA-SE Vaccine ID-G305
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| NCI_META_CUI | CL458226
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| PDQ_Closed_Trial_Search_ID | 756236
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| code | C113432
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| prefixIRI | NCIT:C113432
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| in_subset |
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| Display_Name | NY-ESO-1/GLA-SE Vaccine ID-G305
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| Preferred_Name | NY-ESO-1/GLA-SE Vaccine ID-G305
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| Contributing_Source | CTRP
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| Maps_To | NY-ESO-1/GLA-SE Vaccine ID-G305
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| NCI_Drug_Dictionary_ID | 756236
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 756236
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| Semantic_Type | Pharmacologic Substance
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