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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Islet Amyloid Polypeptide | |
| Synonyms |
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| Definitions |
Islet amyloid polypeptide (89 aa, ~10 kDa) is encoded by the human IAPP gene. This protein plays a role in the regulation of glucose metabolism. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C112881 |
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| code |
C112881
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| definition |
Islet amyloid polypeptide (89 aa, ~10 kDa) is encoded by the human IAPP gene. This protein plays a role in the regulation of glucose metabolism.
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| DesignNote |
The mature islet amyloid polypeptide protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. Homodimerization may be the first step of amyloid formation. (UniProt) Islet amyloid polypeptide is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas. (UniProt)
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| label |
Islet Amyloid Polypeptide
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| OMIM_Number |
147940
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| Preferred_Name |
Islet Amyloid Polypeptide
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| prefixIRI |
NCIT:C112881
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| prefLabel |
Islet Amyloid Polypeptide
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| Semantic_Type |
Amino Acid, Peptide, or Protein Hormone
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| Swiss_Prot |
P10997
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| UMLS_CUI |
C0063684
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| subClassOf |
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