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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1127
http://purl.obolibrary.org/obo/NCIT_C1127
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|---|---|
| Preferred Name | Omacetaxine Mepesuccinate |
| Definitions |
A semisynthetic formulation of the cytotoxic plant alkaloid homoharringtonine isolated from the evergreen tree Cephalotaxus with potential antineoplastic activity. Omacetaxine binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. This agent also induces differentiation and apoptosis in some cancer cell types.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A semisynthetic formulation of the cytotoxic plant alkaloid homoharringtonine isolated from the evergreen tree Cephalotaxus with potential antineoplastic activity. Omacetaxine binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. This agent also induces differentiation and apoptosis in some cancer cell types. |
|---|---|
| prefLabel | Omacetaxine Mepesuccinate
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| label | Omacetaxine Mepesuccinate
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| PDQ_Closed_Trial_Search_ID | 39476
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| code | C1127
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| Has_Target | |
| prefixIRI | NCIT:C1127
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| in_subset |
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| Display_Name | Omacetaxine Mepesuccinate
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| Preferred_Name | Omacetaxine Mepesuccinate
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| FDA_UNII_Code | 6FG8041S5B
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C29H39NO9
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| Maps_To | Omacetaxine Mepesuccinate
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| CAS_Registry | 26833-87-4
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| NSC Number | 141633
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| NCI_Drug_Dictionary_ID | 39476
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| Legacy Concept Name | Homoharringtonine
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the plant alkaloid family of drugs.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39476
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0062941
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| Delete | Subject | Author | Type | Created |
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