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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C111997
http://purl.obolibrary.org/obo/NCIT_C111997
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|---|---|
| Preferred Name | Anti-HER3 Monoclonal Antibody GSK2849330 |
| Definitions |
A monoclonal antibody directed against the human epidermal growth factor receptor 3 (HER3; ERBB3) with potential antineoplastic activity. Anti-HER3 monoclonal antibody GSK2849330 binds to HER3 and inhibits its activation. This may prevent HER3-mediated signaling and inhibit HER3-dependent tumor cell proliferation and differentiation. HER3, a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, is frequently overexpressed in tumors and is associated with poor prognosis and drug resistance; it has no active kinase domain but is activated through heterodimerization with other members of the EGFR receptor family, such as HER2.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A monoclonal antibody directed against the human epidermal growth factor receptor 3 (HER3; ERBB3) with potential antineoplastic activity. Anti-HER3 monoclonal antibody GSK2849330 binds to HER3 and inhibits its activation. This may prevent HER3-mediated signaling and inhibit HER3-dependent tumor cell proliferation and differentiation. HER3, a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, is frequently overexpressed in tumors and is associated with poor prognosis and drug resistance; it has no active kinase domain but is activated through heterodimerization with other members of the EGFR receptor family, such as HER2. |
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| prefLabel | Anti-HER3 Monoclonal Antibody GSK2849330
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| label | Anti-HER3 Monoclonal Antibody GSK2849330
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| NCI_META_CUI | CL454286
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| PDQ_Closed_Trial_Search_ID | 754219
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| code | C111997
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| Has_Target | |
| prefixIRI | NCIT:C111997
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| in_subset |
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| Display_Name | Anti-HER3 Monoclonal Antibody GSK2849330
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| Preferred_Name | Anti-HER3 Monoclonal Antibody GSK2849330
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| Contributing_Source | CTRP
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| Maps_To | Anti-HER3 Monoclonal Antibody GSK2849330
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| NCI_Drug_Dictionary_ID | 754219
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 754219
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Immunologic Factor
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