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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C111758
http://purl.obolibrary.org/obo/NCIT_C111758
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|---|---|
| Preferred Name | Mitochondrial Oxidative Phosphorylation Inhibitor ATR-101 |
| Definitions |
An orally bioavailable inhibitor of mitochondrial oxidative phosphorylation with potential antineoplastic activity. Upon administration, ATR-101 inhibits the activity of F1F0-ATP synthase, elevates the mitochondrial membrane potential and depletes ATP in adrenocortical cells. The mitochondrial dysfunction caused by the release of reactive oxygen and triggered cytochrome c release leads to caspase-mediated cell death. ATR-101 may be useful in treating certain types of adrenocortical carcinoma.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable inhibitor of mitochondrial oxidative phosphorylation with potential antineoplastic activity. Upon administration, ATR-101 inhibits the activity of F1F0-ATP synthase, elevates the mitochondrial membrane potential and depletes ATP in adrenocortical cells. The mitochondrial dysfunction caused by the release of reactive oxygen and triggered cytochrome c release leads to caspase-mediated cell death. ATR-101 may be useful in treating certain types of adrenocortical carcinoma. |
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| label | Mitochondrial Oxidative Phosphorylation Inhibitor ATR-101
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| prefLabel | Mitochondrial Oxidative Phosphorylation Inhibitor ATR-101
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| in_subset |
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| Preferred_Name | Mitochondrial Oxidative Phosphorylation Inhibitor ATR-101
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| Is_Value_For_GDC_Property | |
| Display_Name | Mitochondrial Oxidative Phosphorylation Inhibitor ATR-101
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| Maps_To | Mitochondrial Oxidative Phosphorylation Inhibitor ATR-101
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| PDQ_Open_Trial_Search_ID | 753012
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| prefixIRI | NCIT:C111758
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| NCI_Drug_Dictionary_ID | 753012
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| Contributing_Source | CTRP
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| subClassOf | |
| code | C111758
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| type | |
| PDQ_Closed_Trial_Search_ID | 753012
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| NCI_META_CUI | CL454145
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