Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1113
http://purl.obolibrary.org/obo/NCIT_C1113
Preferred Name

Genistein
Definitions
A soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. (NCI04)
prefLabel
Genistein
label
Genistein
CHEBI_ID
CHEBI:28088
PDQ_Closed_Trial_Search_ID
43214
code
C1113
Has_Target
Unit
mcg
prefixIRI
NCIT:C1113
in_subset
Display_Name
Genistein
Preferred_Name
Genistein
FDA_UNII_Code
DH2M523P0H
Contributing_Source
CRCH
CTRP
FDA
Chemical_Formula
C15H10O5
Maps_To
Genistein
CAS_Registry
446-72-0
NSC Number
36586
NCI_Drug_Dictionary_ID
43214
Legacy Concept Name
Genistein
INFOODS
GNSTEIN
type
ALT_DEFINITION
An isoflavone found in soy products. Soy isoflavones are being studied to see if they help prevent cancer.
An isoflavone with a hydroxyl group on the B-ring and a second hydroxyl group on the A-ring.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
43214
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0061202
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