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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Gallium Nitrate | |
| Synonyms |
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| Definitions |
A hydrated nitrate salt of the group IIIa element gallium with potential use in the treatment of malignancy-associated hypercalcemia. Gallium nitrate localizes preferentially to areas of bone resorption and remodeling and inhibits osteoclast-mediated resorption by enhancing hydroxyapatite crystallization and reduction of bone mineral solubility. This agent also increases calcium and phosphorous deposition into bone and may increase collagen synthesis. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C1109 |
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| ALT_DEFINITION |
A drug that lowers blood calcium. Used as treatment for hypercalcemia (too much calcium in the blood) and for cancer that has spread to the bone (bone metastases).
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| CAS_Registry |
135886-70-3
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| Chemical_Formula |
Ga.3NO3.9H2O
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| code |
C1109
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| Contributing_Source |
FDA
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| definition |
A hydrated nitrate salt of the group IIIa element gallium with potential use in the treatment of malignancy-associated hypercalcemia. Gallium nitrate localizes preferentially to areas of bone resorption and remodeling and inhibits osteoclast-mediated resorption by enhancing hydroxyapatite crystallization and reduction of bone mineral solubility. This agent also increases calcium and phosphorous deposition into bone and may increase collagen synthesis. (NCI04)
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| FDA_UNII_Code |
VRA0C6810N
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| in_subset | ||
| label |
Gallium Nitrate
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| Legacy Concept Name |
Gallium_Nitrate
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| NCI_Drug_Dictionary_ID |
39249
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| NSC Number |
15200
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| PDQ_Closed_Trial_Search_ID |
39249
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| PDQ_Open_Trial_Search_ID |
39249
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| Preferred_Name |
Gallium Nitrate
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| prefixIRI |
NCIT:C1109
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| prefLabel |
Gallium Nitrate
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| Semantic_Type |
Pharmacologic Substance Inorganic Chemical
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| UMLS_CUI |
C0061008
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| subClassOf |
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