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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1106
http://purl.obolibrary.org/obo/NCIT_C1106
|
|---|---|
| Preferred Name | Fotemustine |
| Definitions |
A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier. |
|---|---|
| prefLabel | Fotemustine
|
| label | Fotemustine
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| PDQ_Closed_Trial_Search_ID | 38865
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| code | C1106
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| prefixIRI | NCIT:C1106
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| in_subset | |
| Preferred_Name | Fotemustine
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| FDA_UNII_Code | GQ7JL9P5I2
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| Contributing_Source | FDA
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| Chemical_Formula | C9H19ClN3O5P
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| Maps_To | Fotemustine
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| CAS_Registry | 92118-27-9
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| NCI_Drug_Dictionary_ID | 38865
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| Legacy Concept Name | Fotemustine
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of brain tumors and metastatic melanoma of the eye. It is a type of nitrosourea.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 38865
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0060696
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