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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1102
http://purl.obolibrary.org/obo/NCIT_C1102
|
|---|---|
| Preferred Name | Fludarabine Phosphate |
| Definitions |
The phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth. |
|---|---|
| prefLabel | Fludarabine Phosphate
|
| label | Fludarabine Phosphate
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| CHEBI_ID | CHEBI:63599
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| PDQ_Closed_Trial_Search_ID | 486428
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| code | C1102
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| Has_Target | |
| prefixIRI | NCIT:C1102
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| in_subset |
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| Display_Name | Fludarabine Phosphate
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| Preferred_Name | Fludarabine Phosphate
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| FDA_UNII_Code | 1X9VK9O1SC
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C10H13FN5O7P
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| Maps_To | Fludarabine Phosphate
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| CAS_Registry | 75607-67-9
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| NSC Number |
312887
328002
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| NCI_Drug_Dictionary_ID | 486428
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| Legacy Concept Name | Fludarabine_Phosphate
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| type | |
| ALT_DEFINITION | A drug used to treat B-cell chronic lymphocytic leukemia (CLL) that has not responded to treatment with other anticancer drugs or that has gotten worse. It is also being studied in the treatment of other types of cancer. Fludara blocks cells from making DNA and may kill cancer cells. It is a type of purine antagonist and a type of ribonucleotide reductase inhibitor.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 486428
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| Accepted_Therapeutic_Use_For | Chronic Lymphocytic Leukemia
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI | C0060483
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