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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1098
http://purl.obolibrary.org/obo/NCIT_C1098
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|---|---|
| Preferred Name | Fenretinide |
| Definitions |
An orally-active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types. This agent also inhibits tumor growth by modulating angiogenesis-associated growth factors and their receptors and exhibits retinoid receptor-independent apoptotic properties. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally-active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types. This agent also inhibits tumor growth by modulating angiogenesis-associated growth factors and their receptors and exhibits retinoid receptor-independent apoptotic properties. (NCI04) |
|---|---|
| prefLabel | Fenretinide
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| label | Fenretinide
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| CHEBI_ID | CHEBI:42588
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| PDQ_Closed_Trial_Search_ID | 39582
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| code | C1098
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| Has_Target | |
| prefixIRI | NCIT:C1098
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| in_subset |
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| Display_Name | Fenretinide
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| Preferred_Name | Fenretinide
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| FDA_UNII_Code | 187EJ7QEXL
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C26H33NO2
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| Maps_To | Fenretinide
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| CAS_Registry | 65646-68-6
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| NSC Number | 374551
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| NCI_Drug_Dictionary_ID | 39582
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| Legacy Concept Name | Fenretinide
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment and prevention of some types of cancer. Fenretinide may cause ceramide (a wax-like substance) to build up in tumor cells and kill them. It is a type of retinoid, which are substances related to vitamin A.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39582
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0060197
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